When starting semaglutide, individuals may experience several effects related to its intended therapeutic action as well as potential side effects. Here's what people can generally expect when they begin taking semaglutide:

1. Blood sugar management: Semaglutide works to lower blood sugar levels by stimulating insulin secretion and reducing glucagon secretion, both of which help to control blood sugar levels. People may notice improvements in their blood sugar levels over time.

2. Weight loss: Semaglutide is associated with weight loss in many individuals. This effect can be noticeable, and some people may experience a significant reduction in body weight over time.

3. Decreased appetite: Semaglutide can lead to a decrease in appetite, which contributes to its weight-loss effect. People may find that they feel less hungry and have fewer cravings for food.

4. Injection site reactions: Redness, swelling, or itching at the injection site is common, especially initially. These reactions typically diminish over time.

5. Gastrointestinal effects: Nausea, vomiting, diarrhea, or abdominal discomfort are common side effects when starting semaglutide. These symptoms often improve as the body adjusts to the medication.

6. Improved glycemic control: With consistent use, people typically experience better control over their blood sugar levels, leading to reduced risks of diabetes-related complications.

7. Routine monitoring: Regular monitoring of blood sugar levels and potential side effects is important when starting semaglutide. Healthcare providers may adjust the dosage or provide additional guidance based on individual responses to the medication.

8. Other potential effects: Some individuals may experience less common side effects such as hypoglycemia, increased heart rate, or, rarely, more serious issues like pancreatitis or kidney problems.

Semaglutide is a medication used primarily for the treatment of type 2 diabetes. Like any medication, it can have side effects. Common side effects of semaglutide may include:

1. Nausea: This is one of the most commonly reported side effects. It usually occurs when treatment is initiated and may decrease over time.

2. Vomiting: Some individuals may experience vomiting as a side effect of semaglutide.

3. Diarrhea: Changes in bowel habits, including diarrhea, may occur with semaglutide use.

4. Abdominal pain: Some people may experience abdominal discomfort or pain while taking semaglutide.

5. Constipation: In some cases, semaglutide may cause constipation.

6. Decreased appetite: Semaglutide may lead to a decrease in appetite, which can result in weight loss.

7. Hypoglycemia: While less common compared to some other diabetes medications like insulin or sulfonylureas, semaglutide can cause low blood sugar levels (hypoglycemia), especially when used in combination with other blood sugar-lowering medications.

8. Injection site reactions: Redness, itching, or swelling at the injection site may occur.

9. Increased heart rate: Some individuals may experience an increased heart rate (tachycardia) while taking semaglutide.

10. Pancreatitis: In rare cases, semaglutide may cause inflammation of the pancreas (pancreatitis), which can be serious.

11. Kidney problems: There have been reports of kidney problems associated with semaglutide use, including kidney failure.

12. Thyroid tumors: In animal studies, semaglutide has been associated with an increased risk of thyroid tumors, although it's not clear if this risk applies to humans.